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Upon detecting the actual pathogen by simply TLR, dendritic cells transduce via several signalling pathways getting a pair of adaptor healthy proteins: myeloid distinction marker-88 (MyD88) and Toll-IL-1 receptor domain-containing adaptor inducing IFN�� (TRIF) (20). Following TLR-4 ligation through lipopolysaccharide (LPS), both MyD88- along with TRIF-dependent walkways lead to activating the part